Conjunctivochalasis (CCh)

Case Study Number 03


Conjunctivochalasis (CCh) represents one of the most common age-related eye diseases and is characterized by the presence of redundant folds of the conjunctiva that typically are detected between the eyeball and the eyelids. It is commonly found along the lower lid margin and mechanically interferes with the normal distribution of tears giving rise to unstable tear film (dry eye) and delayed tear clearance (epiphora). The differences between CCh-induced dry eye and aqueous tear deficiency (ATD) are summarized in Table 1. For asymptomatic CCh, no treatment is needed, and patients may be given tear substitutes, lubricants, corticosteroids or antihistamine drops. Persistent symptomatic CCh despite maximal medical treatments to dry eye can be treated using amniotic membrane (AM) transplantation.


Dr. Tseng, received his MD from National Taiwan University Medical School in 1978, and his PhD from University of California San Francisco in 1981. He completed the ophthalmology residency at Johns Hopkins Hospital in 1984 and the cornea and external disease fellowship at Massachusetts Eye & Ear Infirmary, Harvard Medical School, in 1986. He then was as a Charlotte Breyer Rodgers chair professor at Bascom Palmer Eye Institute University of Miami School of Medicine until 2002, when he resigned to assume the position as medical director of the Ocular Surface Center and the Ocular Surface Research & Education Foundation. He served as the first President of International Ocular Surface Society from 2000 to 2004, ad hoc members of NIH study sections from 2002, and the editorial board of Ocular Surface Journal and Cornea Journal. He has given several named lecture such as Ulrich Ollendorff Lecture (1999), Marvin Henry MD Memorial Lecture (2003), Kersley Lecture (2004), Oliver H. Dabezies Jr. M.D. Lecture (2005), James E. McDonald, M.D. Keynote Lecture (2005), Susrata Lecture (2006), and 60 th Japanese Clinical Ophthalmology Congress Keynote Lecture (2006), and received several honors and awards such as Chancellor Award (2002), Senior Achievement Award (2004, and Secretariat Award (2005) from American Academy of Ophthalmology. Dr. Tseng is specialized in ocular surface diseases and reconstruction using new surgical techniques of epithelial stem cell transplantation and amniotic membrane transplantation. He is also the R & D Director, leading a research team of 12 people in Bio-tissue/TissueTech, the leading tissue engineering company in Ophthalmology in the USA.

Financial Interest Disclosure: Dr. Tseng and his family are more than 5% shareholders in TissueTech, Inc. and Bio-Tissue, Inc. which currently distributes AMNIOGRAFT® and PROKERA™.