Conjunctivochalasis (CCh) represents one of the most common age-related eye diseases and is characterized by the presence of redundant folds of the conjunctiva that typically are detected between the eyeball and the eyelids. It is commonly found along the lower lid margin and mechanically interferes with the normal distribution of tears giving rise to unstable tear film (dry eye) and delayed tear clearance (epiphora). The differences between CCh-induced dry eye and aqueous tear deficiency (ATD) are summarized in Table 1. For asymptomatic CCh, no treatment is needed, and patients may be given tear substitutes, lubricants, corticosteroids or antihistamine drops. Persistent symptomatic CCh despite maximal medical treatments to dry eye can be treated using amniotic membrane (AM) transplantation.
